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Sodium valproate with magnesium proved effective for migraine prevention

Sodium valproate with magnesium proved effective for migraine prevention Sodium valproate with magnesium proved effective for migraine prevention
Sodium valproate with magnesium proved effective for migraine prevention Sodium valproate with magnesium proved effective for migraine prevention

What's new?

Patients with migraine can benefit from low dose of sodium valproate when used along with magnesium.

As per the outcomes of a randomized trial published in The Journal of Headache and Pain, magnesium could help boost the anti-migraine characteristics of sodium valproate when used in a combination therapy and decrease the needed dose of valproate for migraine prophylaxis.

To estimate the effectiveness of combination therapy- magnesium and sodium valproate, Samira Khani et al. included migraine patients aged 18 to 65 years. These patients with a minimum of 4 attacks in a month were divided into:

  • Group A (with 82 patients) using sodium valproate therapy;
  • Group B (with 70 patients) using magnesium and sodium valproate combination therapy; and
  • Group C (with 70 patients) using magnesium therapy therapy

At each monthly visit, migraine features, like frequency, severity, period of the attacks, and monthly analgesic usage was noted.

In groups A, B and C, a substantial decrease in all migraine features compared to those reported at the starting point was observed. Other than headache frequency, the other three parameters revealed a noteworthy decrease in group B than group A in the 3rd month.

Additionally, after 3 months, the scores of Headache Impact Test-6 (HIT-6) and Migraine Disability Assessment (MIDAS) considerably decreased in the three groups than those reported at the starting point, with more noteworthy changes in groups A and B as compared to group C as shown in the below figure:


As concluded, this new drug combination can be used as a more effective and safe treatment for migraine prophylaxis.

Source:

The Journal of Headache and Pain

Article:

Comparative study of magnesium, sodium valproate, and concurrent magnesium-sodium valproate therapy in the prevention of migraine headaches: a randomized controlled double-blind trial

Authors:

Samira Khani et al.

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