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Estimating serum NGF and BDNF levels would be beneficial in
finding new therapeutic targets for DPN detection and treatment.
As per recent research led by scientists of Sichuan Provincial People's Hospital and People's Hospital of Aba China, the diabetic peripheral neuropathy (DPN) shows significant associations with brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) serum levels.
DPN is a condition
of autonomic and peripheral nerve injury due to diabetes mellitus. Current
accumulating studies show an association of various serum biomarkers like
vitamin D and uric acid with DPN progression. These serum levels help in early
diagnosis and treatment of DPN. This study involves the investigation of the
involvement of BDNF and NGF among DPN and type 2 diabetes mellitus (T2DM)
people and their effects on the disease progression.
Further, As per ROC
curve analysis, BDNF and NGF levels showed high specificity, accuracy and
sensitivity towards DPN. The course of
disease, postprandial blood glucose level, 2-h PCP level, and serum levels of
NGF and BDNF were considered as the DPN risk factors. These findings suggest NGF
and BDNF serum levels significantly show a relationship with DPN progression.
Med Sci Monit
Diagnostic Significance of Serum Levels of Nerve Growth Factor and Brain Derived Neurotrophic Factor in Diabetic Peripheral Neuropathy
Qin Sun et al.
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