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Self-assembling peptides may be a
viable option to reduce the initiation of caries lesions and to remineralize
them.
A recent study published in 'Journal
of Dentistry' aimed to systematically review the clinical studies investigating
the efficacy of self-assembling peptides (SAP) in remineralization of initial
caries lesions states that SAP could be a viable option in achieving efficient
remineralization of caries lesions.
The prospective controlled,
(non)-randomized trials were searched without time and language filters on Ovid
EMBASE, Central and PubMed to find studies investigating the efficacy of SAP in
comparison to placebo or standard control treatment. Grade Profiler 3.6 and
Risk of Bias 2.0 tool were used for grading the level of evidence and risk of
bias.
A total of 7 randomized controlled trials, five with a split-mouth and two with a parallel-arm design, including 294 affected patients (508 teeth), were identified. Meta-analysis was carried out for SAP (plus fluoride varnish) vs no treatment (plus fluoride varnish) (control treatment). The SAP showed significantly greater optical improvements than the control arm. The reported outcomes were visual analog scale, laser fluorescence, ICDAS score or morphometric measurements as presented in the table below:
Concluding, the
present analysis showed SAP is effective in the remineralization of enamel
caries, but the interpretation should be carried out carefully due to a limited
availability of the evidence.
Journal of Dentistry
Efficacy of a self-assembling peptide to remineralize initial caries lesions - a systematic review and meta-analysis
R.J.Wierichs et al.
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