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Efficacy of Methotrexate and Tripterygium wilfordii combination for rheumatoid arthritis treatment

Efficacy of Methotrexate and Tripterygium wilfordii combination for rheumatoid arthritis treatment Efficacy of Methotrexate and Tripterygium wilfordii combination for rheumatoid arthritis treatment
Efficacy of Methotrexate and Tripterygium wilfordii combination for rheumatoid arthritis treatment Efficacy of Methotrexate and Tripterygium wilfordii combination for rheumatoid arthritis treatment

What's new?

The use of TwHF along with MTX may prove to be useful for treating the RA patients.

For several decades, the extracts of Tripterigium wilfordii Hook F or TwHF (a traditional Chinese herbal medicine) and methotrexate (MTX) have been used for rheumatoid arthritis treatment in China. But,  the efficacy and safety of MTX and TwHF treatment is debatable.

A comprehensive search of databases in both Chinese and English was executed. Two authors independently extracted and investigated data from the selected studies.

A total of 643 patients participated in six randomized controlled trials incorporated in the final analysis. TwHF (in the form of Tripterygium glycosides) was added to the MTX-based therapy in all trials.

For efficacy, the addition of TwHF increased 50% responder rates (RR) (RR 1.337, 95% confidence interval [CI]: 1.188-1.505, P<0.001), and it lowered swollen and tender joint counts, shortened the duration of morning stiffness, decreased the erythrocyte sedimentation rate, and decreased the level of C-reactive protein and rheumatoid factor. For safety, the addition of TwHF did not augement the rate of adverse events (RR 0.824, 95% CI: 0.635-1.068, P=0.143).

Thus, we came to know that

MTX plus TwHF therapy may be a more effective and similar safe strategy for RA management as compared to MTX monotherapy. Although, further large clinical trials to investigate the TwHF add-on therapy are permitted.

Source:

Life Sci.

Article:

Treatment of rheumatoid arthritis with combination of methotrexate and Tripterygium wilfordii: A meta-analysis

Authors:

Wang X et al.

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