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The severity of periodontitis and salivary interleukin-1b are related to psoriasis involvement.
In a cross-sectional study, plaque index, clinical attachment level, and salivary interleukin (IL)-1b were associated with Psoriasis Area Severity Index (PASI) in patients diagnosed with psoriasis. King-JeanWu et al. undertook this study to determine the link between the severity of psoriasis and periodontal damage in 33 people suffering from psoriasis. Full-mouth periodontal assessment was carried out followed by the collection of saliva.
Evaluation of PASI and clinical periodontal parameters including clinical attachment level, probing depth, gingival index, and plaque index was done. Using the Luminex Bio-Plex system, salivary cytokines including interferon-γ, IL-1β, IL-12, IL-17, and tumor necrosis factor (TNF)-α were estimated. Tobacco use, anti-inflammatory agents, and underlying comorbidities were also incorporated in the assessment.
Baseline PASI was considerably linked with plaque index. Notably, PASI at follow-up was positively correlated with clinical attachment level ≥4 mm (%) and IL-1β levels in saliva. People affected with psoriasis and treated with non-steroidal anti-inflammatory agents or topical steroids exhibited a considerably reduced gingival index, probing depth ≥4mm (%), and salivary IL-1β and TNF-α levels. Furthermore, a history of tobacco usage was linked with greater probing depth ≥4mm (%).
Plaque index, IL-1β levels in saliva, and clinical attachment level were linked with PASI. The severity of periodontitis was related to psoriasis involvement. Periodontal inflammation in psoriasis might be altered by anti-inflammatory medicine and tobacco usage. For ascertaining the causal association between periodontitis and psoriasis, further large-scale mechanistic and longitudinal studies are warranted, concluded the study authors.
Journal of the Formosan Medical Association
Severity of periodontitis and salivary interleukin-1β are associated with psoriasis involvement
King-Jean Wu et al.
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