EN | RU
EN | RU

Help Support

Back

No increased risk of infections with Baricitinib in rheumatoid arthritis, study reveals

No increased risk of infections with Baricitinib in rheumatoid arthritis, study reveals No increased risk of infections with Baricitinib in rheumatoid arthritis, study reveals
No increased risk of infections with Baricitinib in rheumatoid arthritis, study reveals No increased risk of infections with Baricitinib in rheumatoid arthritis, study reveals

What's new?

Baricitinib 4 mg appears to be safe in patients with rheumatoid arthritis.

According to a study issued in Southern Medical Journal, the routine use of baricitinib 4 mg did not lead to increased risk of infections in patients with moderate to severe rheumatoid arthritis (RA). But, the occurence of serious adverse events, study withdrawal due to adverse events, or severe infections were not considerably different as compared to the placebo.

To examine the safety of baricitinib, Tracey D Dabal and researchers performed database searching to find the suitable randomized controlled trials comparing baricitinib at a dose of 4 mg versus placebo for RA treatment.

The safety outcomes under consideration were the occurrence of serious adverse events, study withdrawal due to adverse events, all infections, and severe infections. Adjusted risk ratios (RRs) with 95% confidence intervals (CIs) were pooled for safety outcomes. Risk of bias assessed via Cochrane tool.

Four randomized controlled trials with 3106 patients considered. The pooled RR (95% CI) was 1.09 (0.76-1.57) and 1.41 (0.94-2.11) for serious adverse events and study withdrawal due to adverse events, respectively. For all reported- and severe infections, the pooled RR (95% CI) was 1.24 (1.10-1.40) and 0.97 (0.51-2.57).

 

Source:

Southern Medical Journal

Article:

Safety of Baricitinib 4 mg for the Treatment of Moderate to Severe Rheumatoid Arthritis

Authors:

Tracey D Dabal et al.

Comments (0)

You want to delete this comment? Please mention comment Invalid Text Content Text Content cannot me more than 1000 Something Went Wrong Cancel Confirm Confirm Delete Hide Replies View Replies View Replies en ru ua
Try: