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A cream containing linoleic acid (plant-derived skin moisturizing agent)
along with dexpanthenol and ceramide offered better outcomes than 5%
urea cream for improving clinical atopic dermatitis in children.
As compared to urea cream, the use
of linoleic
acid, dexpanthenol and ceramide moisturizing cream can be useful for
improvement of mild-to-moderate atopic dermatitis (AD) in children, suggests a
study published in the Asian
Pacific Journal of Allergy and Immunology.
Phatthanan Somjorn et al. performed this randomized
controlled study to evaluate the effectiveness of
plant-derived, skin-conditioning agent with high proportion of linoleic
acid plus dexpanthenol and ceramide (LDC) cream compared to 5% urea cream for
the treatment of AD.
A total of 38 patients with AD applied LDC cream twice
daily on one side of the body and 5% urea cream on the other side. The altered
scoring of atopic dermatitis (SCORAD) was used to evaluate the clinical
efficacy.
It was found that, 37 out of 38 patients
completed the study, both groups had significantly improved clinical SCORAD
from baseline and after 2 and 4 weeks. Patients in the LDC group experienced
significantly decreased severity of disease as compared to the 5% urea group.
No significant differences were observed in terms of boosting hydration in
stratum corneum in both groups.
Asian Pacific Journal of Allergy and Immunology
A cream containing linoleic acid, 5% dexpanthenol and ceramide in the treatment of atopic dermatitis
Phatthanan Somjorn et al.
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