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Early detection and bundled treatment dramatically reduce postpartum hemorrhage risk

postpartum hemorrhage risk postpartum hemorrhage risk
postpartum hemorrhage risk postpartum hemorrhage risk

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The timely identification of postpartum hemorrhage and the implementation of a bundled treatment results in a decreased risk of severe postpartum hemorrhage, laparotomy for bleeding, or death from bleeding—when compared to standard care in women undergoing vaginal delivery.

In a major international breakthrough, a randomized trial (E-MOTIVE) has demonstrated the effectiveness of early detection and a comprehensive treatment bundle in curtailing the chances of severe postpartum hemorrhage, laparotomy for bleeding, or maternal death from bleeding. This randomized trial was carried out using cluster-randomization to evaluate a comprehensive clinical intervention aimed at addressing postpartum hemorrhage during vaginal delivery.

The intervention comprised a precisely calibrated blood-collection drape designed for early identification of postpartum hemorrhage, along with a bundle of initial response measures (including uterine massage, oxytocic agents, tranexamic acid, intravenous fluids, assessment, and escalation). This intervention was implemented with a specific strategy within the intervention group, while hospitals in the control group administered standard care. The key endpoint measured was a combination of severe postpartum hemorrhage (defined as blood loss of ≥1000 ml), laparotomy for bleeding, or maternal death resulting from bleeding.

Key secondary endpoints assessed encompassed the identification of postpartum hemorrhage and adherence to the therapy bundle. This study, encompassing 80 secondary-level hospitals across Kenya, Nigeria, South Africa, and Tanzania, involved 210,132 patients who underwent vaginal delivery. The intervention group received the multicomponent clinical intervention, while the control group provided standard care.

Key findings:

  • The primary outcome (composite of severe postpartum hemorrhage, laparotomy for bleeding, or maternal death from bleeding) occurred in 1.6% of patients in the intervention group compared to 4.3% in the usual-care group.
  • Early detection of postpartum hemorrhage was considerably higher in the intervention group (93.1%) compared to the usual-care group (51.1%).
  • Adherence to the treatment bundle was remarkable in the intervention group (91.2%) compared to a mere 19.4% in the usual-care group.

The results indicate that early detection of postpartum hemorrhage, coupled with the implementation of a bundled treatment approach, substantially minimizes the risk of severe outcomes among patients undergoing vaginal delivery. This breakthrough has the potential to reshape postpartum care protocols globally, offering a more effective and standardized approach to managing this critical condition.

These findings are expected to influence clinical practices and guidelines, highlighting the importance of a comprehensive approach to postpartum hemorrhage management, ultimately improving maternal outcomes. Further research and implementation strategies are likely to be developed based on the success of this trial.

Source:

The New England Journal of Medicine

Article:

Randomized Trial of Early Detection and Treatment of Postpartum Hemorrhage

Authors:

Ioannis Gallos et al.

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