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Crush cytology is a quick and
effective diagnostic tool for gastrointestinal tract malignancy.
As per the
results of the latest study issued in Endoscopy International
Open, Crush smear cytology was found to be an extremely
sensitive, specific, time-saving and cost-effective diagnose tool for
gastrointestinal lesions. It is an
added value to the histology to boost the diagnostic accuracy and hasten
decision making for lesions management.
This prospective, cross-sectional, single-centre study comprised 451 patients with suspected malignant lesions. About
26.4% of patients had lesions in esophagus and GE junction, 16.6% in the stomach,
5.9% in ampulla & duodenum, and 50.9% in colorectal. The crush cytologic diagnosis
was associated with histology to ascertain the diagnostic accuracy. Out
of these, 92.9% were considered as malignant lesions and 7.1% as non-malignant.
Crush cytology results portrayed 84.5%
patients being positive for malignancy, 8.9 % patients being negative for
malignancy and 6.6% of patients being suspicious for malignancy.
In general, sensitivity
was 97.3% , specificity was 90 %, positive predictive value was 99.2 %, negative predictive value was 72.5 % with
diagnostic accuracy of 96.9 %.
Even though crush cytology proved to be efficient
diagnostic tool, but it cannot entirely substitute histopathological test
concerning specific tumor type and grading, and cases in which cytology is
doubtful, Pankaj
Desai et al. deduced.
Endoscopy International Open
Crush cytology: an expeditious diagnostic tool for gastrointestinal tract malignancy
Pankaj Desai et al.
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