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With remarkable safety, the transdermal
buprenorphine patch effectively decreased pain and need of analgesics for pain
control after total knee arthroplasty surgery in elderly patients.
A prospective
randomized study confirms the efficacy and safety of Transdermal buprenorphine
(TDB) patch for relieving postoperative pain after total knee arthroplasty
(TKA) surgery.
The study
included 200 senior citizen patients (60-75 years old) who underwent TKA
surgery with neuraxial blockade anaesthesia via periarticular local anaesthetic
infiltration and epidural/femoral nerve block infusion for 72 hours after
surgery.
The study
population was divided into 2 groups as Group A and B. Group A patients were
transdermally applied with a 5mcg patch of buprenorphine and Group B patients
received paracetamol and tramadol combination. As rescue analgesia diclofenac
iv was administered to all the patients. The outcomes like side effects, pain
at rest and pain on movement were compared over 7 days by numerical rating
scale.
It was found that
pain at rest and on movement was significantly lower and less rescue analgesia
was required in Group A. Respiratory depression and local erythema were
observed in 1 and 3 patients respectively.
Thus, the TDB
patch can be safely used for postoperative pain control after TKA surgery.
The Journal of Arthroplasty
Efficacy and Safety of Buprenorphine Transdermal Patch for Immediate Postoperative Analgesia After Total Knee Arthroplasty Surgery.
Sanjay Londhe et al.
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