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Intra-articular
injections failed to provide long term symptomatic relief or improve disease
activity in patients with knee OA, irrespective of the patterns of injection
use.
The
study aimed to describe and analyse longitudinal use of intra-articular
injections after treatment initiation among adults with radiographically
confirmed knee osteoarthritis (OA) concluded that the proportion of patients
switching injection use and one-time users was substantial.
The Osteoarthritis Initiative (OAI) data was used to enrol participants who
were radiographically confirmed of suffering OA (Kellgren–Lawrence grade (K–L)
≥ 2) in ≥1 knee at baseline. A total data of 9 years was used in which, 412
participants newly initiating hyaluronic acid or corticosteroid injections with
their index visit were identified. For each type of injection initiated the
clinical and socio-demographic characteristics were described by patterns of
treatments i.e. one-time use, switched, or continued injections. Multinomial
logistic models evaluated the extent to which patient-reported symptoms
(post-initial injection and changes over time) were associated with patterns of
injection use.
The findings evaluated that of these initiating injections, ∼19% switched, ∼21%
continued injection type, and ∼60% did not report any additional injections. In
participants who initiated corticosteroid injections, greater symptoms
post-initial injection were found to be associated with lower odds of continued
use compared to one-time users (adjusted odds ratio (aOR) for Western Ontario
and McMaster Universities Arthritis Index (WOMAC) pain: 0.91; 95%, confidence
interval (CI): 0.83 to 0.99; aORstiffness: 0.77; CI: 0.63 to 0.94; aORphysical
function: 0.97; CI: 0.94 to 1.00). The symptom that changed with time (e.g.,
worsened or improved) were not correlated with patterns of injections use.
But the symptoms post-initial injection found to be linked with patterns of
injection use. There is a need to explore patterns of the lack of impact on
patient-reported symptoms.
Osteoarthritis and Cartilage
Patterns of intra-articular injection use after initiation of treatment in patients with knee osteoarthritis: data from the osteoarthritis initiative
Liu SH et al.
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