Administration of vitamin D in individuals having endometriosis led to significant improvement of pelvic pain, high-sensitivity C-reactive protein, total-/HDL-cholesterol ratio, and total antioxidant capacity levels. However, the metabolic profiles and other clinical symptoms were not affected.

A double-blind, randomized, placebo-controlled study was performed to investigate the impact of vitamin D intake on metabolic profiles and clinical symptoms in individuals suffering from endometriosis.

About 60 participants (age 18-40 years) suffering from endometriosis were recruited. Individuals were randomized to receive either a 50,000 IU vitamin D group (n=30) or placebo group (n=30) each two weeks for 12 weeks.

Supplementing vitamin D substantially decreased pelvic pain (β - 1.12) and total-/HDL-cholesterol ratio (β - 0.29) when compared to the placebo-recipients. Furthermore, vitamin D consumption led to a considerable decline in high-sensitivity C-reactive protein (β - 0.64 mg/L) and a considerable rise in total antioxidant capacity (β - 47.54 mmol/L) compared with the placebo.

Vitamin D intake effectively relieves pelvic pain in endometriosis patients.