Older people (≥sixty-five years) having eosinophilic esophagitis have a high therapeutic response to topical corticosteroids therapy.

A retrospective cohort study was performed to investigate the response to topical steroid therapy in the older and younger population suffering from eosinophilic esophagitis.

This study incorporated people with newly diagnosed eosinophilic esophagitis and treated with topical corticosteroids. Recording of histologic responses, global symptom responses, and endoscopic alterations was done. Comparison between older eosinophilic esophagitis people (≥sixty-five years) and younger eosinophilic esophagitis people (<sixty-five years) was done.

Identification of 467 eosinophilic esophagitis people treated with topical corticosteroids, 12 (3%) of whom were ≥sixty-five years was done. In comparison with younger people, older people exhibited a longer duration of symptoms and poor endoscopy scores. However, most of the clinical features were comparable. The post-therapy peak eosinophil counts were reported to trend higher in the younger population (25.0 vs 5.5).

The histological response was higher in the older population at <15 eosinophils per high-power field [eos/hpf], ≤6 eos/hpf, and <1 eos/hpf, as shown in Table 1:

The older age was independently linked with elevated odds of histologic response (adjusted odds ratio 8.48).

Eosinophilic esophagitis people ≥sixty-five years exhibited a greater likelihood of responding to topical steroids therapy. It is suggested to include the older population with eosinophilic esophagitis in future trials and investigate them more closely