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This study evaluated the effectiveness and safety of topical NSAIDs in managing a frozen shoulder or adhesive capsulitis of the shoulder.
Loxoprofen hydrogel patches are more effective and have a similar safety profile compared to flurbiprofen cataplasm in treating frozen shoulder.
This study evaluated the effectiveness and safety of topical NSAIDs in managing a frozen shoulder or adhesive capsulitis of the shoulder.
Overall, 108 patients suffering from moderate to severe frozen shoulder were divided into two groups. The experimental group (n=72) used Loxoprofen hydrogel patches daily with rehabilitation physiotherapy, while the control group (n=36) used Flurbiprofen cataplasms twice daily with the same physiotherapy. Efficacy was measured by the Constant-Murley Score (CMS), and data on adverse events and patient satisfaction were collected.
After 14 days, the experimental group had a 66.67% effective rate, compared to 41.67% in the control group. The difference in effectiveness was 25%. Both treatments had comparable safety profiles, with minimal adverse events.
Loxoprofen hydrogel patches provide superior pain relief and functional improvement for frozen shoulder compared to Flurbiprofen cataplasms, with a similar safety profile.
European Review for Medical and Pharmacological Sciences
Efficacy and safety of topical NSAIDs combined with physiotherapy for frozen shoulder: a randomized controlled trial
G-Y Chen et. al.
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