The anti-inflammatory, analgesic and antipyretic effects of dexamethasone reported being beneficial in the postoperative pain. However, its analgesic and opioid-sparing effect have not been well examined in women with post-cesarean. Therefore, the current trial showed the additive impact of dexamethasone 8 mg to a multimodal postoperative analgesic regimen.

The postoperative analgesia can be improved along with reduced opioid consumption with the usage of a single perioperative dose of Dexamethasone. Although, this analgesic and opioid-sparing effect of Dexamethasone has not been well evaluated in the multimodal analgesic regimen among women's post-cesarean delivery.

A total of 52 women having cesarean delivery with spinal anaesthesia were randomised to obtained either Dexamethasone 8 mg or placebo following delivery and clamping of the umbilical cord. Total opioid intake in the 24 hours after the cesarean delivery was considered as the analysis's primary outcome. Investigators hypothesized that a single dosage of intravenous dexamethasone, delivered as part of a multimodal analgesia regimen following spinal anaesthesia for cesarean delivery, would considerably reduce postoperative opioid intake.

The participants received Dexamethasone showed12 mg median (IQR) opioid intake in the first 24 hours following cesarean delivery as compared to the 15 mg with placebo. No significant median difference in opioid consumption at 24 hours was noticed between the groups.

Addition of 8 mg intravenous Dexamethasone to a multimodal postoperative analgesic regimen which comprised intrathecal morphine, in females who had a cesarean delivery under spinal anaesthesia, did not show any decrease in 24-hour postoperative opioid intake.