People infected with coronavirus disease witness neuronal presentations varying with infection progression.

This systematic review was carried out for determining the association of neurological manifestations with coronavirus disease.

Databases like Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Scopus, and Embase were searched to find out relevant studies. The peer-reviewed studies issued in Spanish and English that reported data on neurological associations of people with suspected or lab-confirmed coronavirus disease were taken into consideration. Diagnoses, symptom severity, and nervous signs or symptoms were the endpoints ascertained.

A total of 45 studies (1 retrospective study, 21 case reports, 2 prospective reviews, 9 observational studies, 3 case series, 9 retrospective reviews) were identified. Vomiting, nausea, fibromyalgia, and headache were the most commonly noted neuronal presentations. Pain, error in visual acuity (deformity in sharpness or clarity of vision), ageusia and anosmia might occur in parallel.

In people who were kept in quarantine and those people having long-stay admissions in the medical care settings, significant afflictions in the form of post-traumatic stress symptoms, confusion, post-intensive care syndrome, anxiety, and anger were noted. The coronavirus disease can elicit cognitive dysfunction.

People having more serious infections showed uncommon manifestations, like Guillain-Barré syndrome, encephalopathy, rhabdomyolysis, and acute cerebrovascular diseases (stroke, intracerebral haemorrhage).

Medical care professionals must be familiar with the divergent neurological symptoms for curbing misdiagnosis and must restrict the long-term sequelae. The policymakers and medical care planners should prepare for this eventuality, while the ongoing investigations raise our knowledge on chronic and acute neurological complications of SARS-CoV-2.