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To investigate the association between circulating Chlamydia pneumoniae (C pneumoniae) immunoglobulin G (IgG) antibody and migraine in Indian patients.
Migraine is a
chronic neurologic disease caused due to the infection and inflammation which
affects both the genders. In this study, Cp (Chlamydia pneumoniae) infection
was found to be independently associated with migraine.
To investigate
the association between circulating Chlamydia pneumoniae (C pneumoniae)
immunoglobulin G (IgG) antibody and migraine in Indian patients.
A total of 300
migraine patients and 150 age-matched and sex-matched controls were recruited
from the Department of Neurology at Yashoda Hospital in Hyderabad, India,
during the study period between August 2011 and July 2013. All patients and
controls were assessed for the presence of the C pneumoniae IgG antibody and
also C-reactive protein (CRP) as well as for depression, which was assessed by
the Hamilton Depression Rating Scale (HDRS).
Of the patients
with migraine, 69% were female and the mean age ± standard deviation (SD) was
45.8 ± 4.8 years (range 18 to 62 years). The C pneumoniae IgG antibody was
present in 151 of the patients (50.3%; P < .0001), CRP in 180 (60%; P <
.0001), depression in 270 (90%; P < .0001), and history of sleep disturbances
in 70 (23.3%; P < .0001); all measurements were significantly higher in
migraine patients compared with controls. After adjustment for multiple
logistic regression analyses, C pneumoniae IgG antibody positivity (odds ratio
[OR] 2.6; 95% confidence interval [CI] = 1.3 to 3.7), CRP positivity (OR 6.2;
95% CI = 3.3 to 11.6), mild depression (OR 16.9; 95% CI = 6.5 to 39.4), and
history of sleep disturbance (OR 2.1; 95% CI = 1.1 to 3.1) were independently
associated with migraine.
This study showed
that the presence of C pneumoniae IgG antibody was independently associated
with migraine in Indian patients.
J Oral Facial Pain Headache. 2016 Spring;30(2):150-5
Association between chlamydia pneumoniae and migraine: A study from a tertiary center in India
Chaudhuri et al.
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