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To find the causal association between constipation and hypertension (high blood pressure) using Mendelian randomization research.
Patients with hypertension or high BP may be more prone to developing constipation (irregular bowel movements), signifying a close connection between the two.
To find the causal association between constipation and hypertension (high blood pressure) using Mendelian randomization research.
In this 2-way, 2-sample Mendelian randomization research, the genetic variants related to constipation were obtained from a genome-wide association study involving people of European descent, comprising 15,902 cases and 395,721 controls.
Similarly, genetic links for hypertension were sourced from the data from a genome-wide association study of European ancestry, which included 54,358 cases and 408,652 controls.
Genetic predisposition to hypertension was linked to a greater risk of constipation (OR: 3.459, 95% CI: 1.820–6.573, P < .001).
Conversely, the inverse Mendelian randomization analysis exhibited no causal effect of constipation on hypertension (OR: 0.999, 95% CI: 0.987–1.011). These connotations remained steady in sensitivity analyses, with no evidence of pleiotropy.
This study suggests a causal connection between hypertension and constipation.
Medicine
Causal relationship between hypertension and risk of constipation: A 2-way 2-sample Mendelian randomization study
Rong Wang et al.
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