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A cross-sectional study was performed to explore the function of interferon gamma (IFN-γ) in terms of reduction in numbers and severity of COVID-19 patients in the parasitic infected regions.
This study suggested
the possible defensive role of parasitic infections against COVID-19 since the
incidence and severity of SARS-CoV-2 decreased in people with parasitic
infections compared to those who had SARS-CoV-2 alone.
A cross-sectional study was performed to explore
the function of interferon gamma (IFN-γ)
in terms of reduction in numbers and severity of COVID-19 patients in the
parasitic infected regions.
A total of 375
COVID-19 infected individuals aged 18 to 69 years old were included. Complete
examinations were performed, specifically focused on SARS-CoV-2 nucleic acid
and Toxoplasma IgG and IgM antibody detection, stool test, and
quantitative analysis of IFN-γ.
More than half of the patients had chest manifestation
either alone (54.7%) or along with gastrointestinal (GIT) manifestations (19.7%).
However, 25.6% presented with GIT symptoms. About 72.8% of patients
with mild
and
20.7% with severe
COVID-19
had
parasitic
infections. The most frequent parasitic
infections among COVID-19 patients were Cryptosporidium, Blastocyst,
Toxoplasma gondii, and Giardia.
The affirmative role
of parasitic infections in the modulation of human immune response to
coronavirus infection was very clear from the elevated level of IFN- γ in
moderate cases versus declined levels in severe cases.
Gut Pathogens
Role of interferon gamma in SARS-CoV-2-positive patients with parasitic infections
Enas Fakhry Abdel-Hamed et al.
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