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A meta-analysis and systematic review were performed to explore the relationship between cardiovascular risk factors and in-hospital death in subjects suffering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
In coronavirus disease 2019 (COVID-19) patients, diabetes,
and older age are linked with a greater risk of in-hospital death. Male gender,
smoking, and hypertension were not independently linked with adverse and fatal
outcomes.
A meta-analysis and systematic review were performed to
explore the relationship between cardiovascular risk factors and in-hospital
death in subjects suffering from severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2).
Databases like SCOPUS, Cochrane, Web of Sciences, and
MEDLINE were explored for prospective or retrospective observational studies
reporting data on death and cardiovascular risk factors in coronavirus-infected
subjects. To determine the link between cardiovascular risk factors and the
incidence of death during hospitalization, the univariable and multivariable
age-adjusted assessments were performed. The analysis incorporated 45 studies
recruiting 18,300 participants. The incidence of death during hospitalization
was the major outcome.
Pooled estimate of in-hospital death was 12%. The
univariable meta-regression analysis illustrated a substantial link between age
(coefficient: 1.06), diabetes (coefficient: 1.04), and hypertension
(coefficient: 1.01) with in-hospital mortality.
Smoking and the male gender did not considerably impact mortality. At
multivariable meta-regression assessment, diabetes was considerably linked with
mortality during hospitalization (coefficient: 1.02). Hypertension was found to
be no longer vital after adjusting for age (coefficient: 1.00). In all the
multivariable models, a vital link between age and in-hospital death was
witnessed.
Diabetes and older age can
elevate the risk of in-hospital death. Male gender, smoking, and hypertension
are not independently associated with adverse outcomes.
BMC Cardiovascular Disorders
Cardiovascular risk factors and mortality in hospitalized patients with COVID-19: systematic review and meta-analysis of 45 studies and 18,300 patients
Angelo Silverio et al.
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