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A randomized, placebo-controlled, triple-blinded, single-center study was performed to explore the analgesic effect of ibuprofen and also whether ibuprofen impacts the functional, biochemical, radiological, and densitometrical outcomes following a colles fracture.
In patients with colles fracture, ibuprofen appears to be a
bone-safe analgesic therapy and may be actively translated into the other
fields of cancellous bone fracture therapy.
A randomized, placebo-controlled, triple-blinded,
single-center study was performed to explore the analgesic effect of ibuprofen
and also whether ibuprofen impacts the functional, biochemical, radiological, and densitometrical outcomes
following a colles fracture.
The study cohort incorporated 96 patients. All the participants were given basic therapy with 1000 mg of acetaminophen four times daily. The placebo cohort was given a placebo for about seven days. The three-day ibuprofen cohort was administered 600 mg ibuprofen thrice daily for the initial three days and a placebo for the next four days. The seven-day ibuprofen cohort was given ibuprofen thrice daily for about seven days.
The fragment migration for five weeks was the primary
endpoint. Alterations in the wrist's range of motion; bone mineral density of
the injured wrist; Disabilities of the Arm, Shoulder and Hand score changes in
serum CrossLaps and osteocalcin; and pain relief were the secondary endpoints.
The analyses were carried out based on the
intention-to-treat approach. No vital differences in the radiological migration
or densitometrical, functional and biochemical effects were noted among the
groups. During the initial three days, the pain score was found to be reduced
in the ibuprofen arm compared to the placebo arm.
Ibuprofen may be a promising
bone-safe analgesic therapy after colles fracture.
Orthopedics
The Influence of Ibuprofen on the Healing of Nonsurgically Treated Colles' Fractures
Marius Aliuskevicius et al.
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