Categories
Change Password!
Reset Password!
This retrospective cohort study aimed to assess the effects of stress ulcer prophylaxis versus no prophylaxis on patient outcomes in sepsis people at risk for gastrointestinal bleeding.
Stress ulcer prophylaxis demonstrated no impact on
hospital mortality, rate of gastrointestinal bleeding, pneumonia, Clostridium
difficile infection, and intensive care unit length of stay in critically ill
adult people with sepsis who
have potential risk factors for gastrointestinal bleeding.
This retrospective cohort study aimed to assess the effects
of stress ulcer prophylaxis versus no prophylaxis on patient outcomes in sepsis
people at risk for gastrointestinal bleeding.
Using data from Medical
Information Mart for Intensive Care III database, a comparison was made between
people who were given stress ulcer prophylaxis with proton pump inhibitors or
histamine-2 receptor antagonists for ≥three days and people who were given no
prophylaxis. For making comparisons between the study groups with equivalent
distributions of study variables, propensity score matching was carried out.
In-hospital mortality was the major endpoint.
Overall, 7,744 participants were incorporated with 6,656 (86.0%) participants in the stress ulcer prophylaxis group and 1,088 (14.0%) participants in the non-stress ulcer prophylaxis group. A 1:1 propensity score matching created 866 participants in each cohort. In terms of in-hospital mortality, gastrointestinal bleeding, pneumonia, Clostridium difficile infection, or intensive care unit length of stay, there were no profound inter-group differences, as shown in Table 1:
Stress ulcer prophylaxis does
not seem to be beneficial for sepsis patients at risk of gastrointestinal
bleeding.
The Journal of Internal Medicine
Stress Ulcer Prophylaxis in Critically Ill Adult Patients with Sepsis at Risk of Gastrointestinal Bleeding: A Retrospective Cohort Study
Minqiang Huang et al.
Comments (0)