A dual regimen composed of 20 or 40 mg Amoxicillin and 3000 mg Vonoprazan for 14 days was safe and efficient as rescue therapy for H. pylori management.

A real-world retrospective study aimed to evaluate the safety and effectiveness of Amoxicillin and Vonoprazan dual regimen as a rescue treatment in Helicobacter pylori (H. pylori)-positive subjects who had failed 1 or more times with their prior intervention.

Clinical information of subjects whose therapy for H. pylori infection had failed 1 ~ 7 times was gathered. As a rescue measure, subjects received 20 or 40 mg Vonoprazan per day and 3000 mg Amoxicillin per day (VA dual therapy) for 14 days. Six weeks after commencing therapy, the status of H. pylori was determined by a 13C-urease breath test. The occurrence of side effects was noted. Overall, 186 subjects comprising 67 men and 119 women were recruited.

Notably, 172 subjects (172/186, 92.5%) had attained successful elimination. Only 14 subjects (7.5%, 14/186) experienced side effects, which included headache, diarrhoea, stomach pain, and skin rashes. The symptoms disappeared on their own and all the side effects were reported to be mild.

Regardless of how many times the subjects had failed and what regimens they had previously utilized, Vonoprazan + Amoxicillin dual therapy could be selected as a "simplified rescue therapy" with a relatively high rate of H. pylori elimination.