Ropivacaine vs. Chloroprocaine for pain management in urgent cesarean sections

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Created On: 26/12/2024

While 3% Chloroprocaine had been commonly used for urgent cesarean deliveries during labor, 0.75% Ropivacaine has emerged as a promising alternative. This study compared their efficacy and safety for extended epidural pain relief in expectant mothers.

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Key take away

For pregnant women undergoing urgent cesarean delivery, 0.75% Ropivacaine is a more appropriate choice when compared to 3% Chloroprocaine.

Background

Method

In this randomized controlled trial, 45 pregnant females requiring emergency cesarean section during labor analgesia period were incorporated. Participants were randomly assigned to get either 0.75% Ropivacaine or 3% Chloroprocaine in a 1:1 ratio. The key endpoint ascertained was the time to onset of the T4 block. It was defined as the duration from the initiation of epidural extension to the loss of cold sensation at the T4 level.

Result

The Ropivacaine group attained loss of cold sensation faster as opposed to the Chloroprocaine group. Fewer subjects in the Ropivacaine group required additional local anesthetics. The Ropivacaine group also reported lower intraoperative visual analog scale (VAS) scores and higher satisfaction, as described in Table 1 below.

There was no significant difference between the groups in terms of motor block degree at T4. Both groups exhibited similar rates of intraoperative complications, with no serious events noted.

Conclusion

For expectant mothers receiving urgent cesarean delivery, 0.75% Ropivacaine resulted in less intraoperative pain treatment, higher satisfaction, and quicker onset time than 3% Chloroprocaine.