Migrain and cluster headaches (CH) are chronic headache disorder with a prevelance of about 15% worldwide. While there are numerous treatment are available for headache disorders, but none of them are ideal in terms of effectiveness and tolerability. This study focus on the use of illegal psychoactive tryptamines such as psilocybin, LSD, and related substances and were reportedly effective for both prophylactic and acute treatment of cluster headache and migraines.

To enhance comprehension about the use of alternative or non-established pharmacological strategies adopted by patients of migraines and cluster headaches.

A qualitative thematic interpretation of the users’ own accounts shown in online forum reviews was directed. The forum boards http://bluelight.org, https://clusterbusters.org/ and https://shroomery.org/ satisfied the inclusion criteria and were adopted for the investigation.

The investigation concluded in six statements: alternative treatment substances; the role of the forum—discovering alternative therapies and community support; dosage and regimens; an urgent requirement for effective therapies; effects and treatment results; and adverse effects. The outcomes present a preception into why, how, and by which substances and approaches, patients seek relief from migraines and cluster headache.

These subjects are in an extreme, vulnerable situation, and illicit psychoactive substances are usually held a last option. Initially, Lysergic acid diethylamide, Psilocybin, and associated psychedelic Tryptamines were reportedly useful for both prophylactic and acute treatment of migraines and cluster headache. Treatment outcomes with Cannabis were more inconsistent. No critical adverse effects were noticed.