Outcomes of restorative reproductive medicine for infertility

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Created On: 16/08/2021

Outcomes of restorative reproductive medicine for infertility

This retrospective observational research aimed to study the outcomes of infertile couples who received restorative reproductive medicine (RRM) therapy.

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Key take away

This study supports the use of restorative reproductive medicine for infertility. Younger women aged less than 35 years and females with a body mass index < 25 had higher chances of having a live birth.

Background

This retrospective observational research aimed to study the outcomes of infertile couples who received restorative reproductive medicine (RRM) therapy.

Method

A total of 370 infertile couples were treated by 2 family physicians specialized in RRM. A retrospective review of the couple’s characteristics, diagnoses, treatments, and outcomes between 1989-2014 was carried out. Kaplan-Meier analysis helped evaluate pregnancy and live birth. The aggregate proportion with pregnancy or with live birth was compared with the help of Fleming-Harrington and weighted Renyi test or the log-rank test.

Result

The mean age of total couples starting the treatment for infertility was 34.8 years. The mean time trying to conceive before the use of RRM was 2.7 years, and 27% of the women had a previous live birth. Mean number of diagnoses per couple was 4.9.

Fertility tracking (80%); medicines to boost cervical mucus production (81%), medicines to promote ovulation (62%), or to maintain the luteal phase (75%); and transfer to female laparoscopy by gynecologists (46%), were the treatment components.

Overall, the cumulative live birth rate at two years was 29%, which was considerably higher for 34% of females under age 35 years and for 40% of women with a body mass index less than 25. In addition, two sets of twins were found, and no higher-order multiple pregnancies. Notably, 58 (92%) births occurred at term out of a total of 63 births.