In individuals with nonoperative back pain of neuropathic origin, the 10 kHz spinal cord stimulation improved leg and back pain, quality of life, pain-linked disability, and medication intake.

An open-label prospective study (Maiden Back Study) was carried to investigate the usage of spinal cord stimulation in subjects with related features of central sensitization like hyperalgesia and allodynia.

The study recruited 21 individuals having back pain and hyperalgesia or allodynia who didn't have previous spinal surgery underwent a spinal cord stimulation trial (administration of electrical impulses epidurally at a pulse width of 30 μsec and frequency of 10 kHz) followed by full implantation. Participants attended the follow-up visits after six and 12 months of spinal cord stimulation.

Utilizing the repeated measure ANOVAs/Friedman tests, the alteration after six and 12 months of spinal cord stimulation were assessed. Utilizing the independent sample t-tests/Mann-Whitney U tests, the differences in response after 12 months of spinal cord stimulation were assessed.

Following six and 12 months of 10 kHz spinal cord stimulation, substantial improvements were witnessed in the quality of life, leg and back pain, pain-associated disability, and morphine equivalence in comparison with baseline. No elevation was noted in the intake of amitriptyline, opioids, gabapentin, or pregabalin in any participant.

About 52% of subjects noted ≥50% alleviation in back pain, 44% attained remission (0-3 cm back pain visual analog scale), 40% witnessed Oswestry Disability Index (ODI) scores between 0 and 40, and 60% witnessed a decline of at least 10 ODI points after 12 months of treatment.

Subjects witnessing a ≥10-point improvement in ODI had considerably longer pain history durations and witnessed considerably better alleviation of back pain, leg pain, and improved quality of life compared to those witnessing <10-point improvement in ODI.

In patients having low back pain of neuropathic origin, spinal cord stimulation appears to be a promising approach to alleviate pain.