The efficacy of nimesulide is comparable to dipyrone monohydrate in alleviating pain in patients with lower molar extractions.

A blind study was carried to assess the efficacy of 100 mg nimesulide and 500 mg dipyrone monohydrate used after dental extractions in order to establish a suitable and accurate analgesic choice after extractions. 

The study recruited 40 participants who underwent lower molar extraction. Participants were allocated into cohorts undergoing treatment with and without ostectomy. Notably, 100 mg nimesulide or 500 mg dipyrone monohydrate were prescribed to participants randomly. Utilizing the visual analogue scale, the pain intensity after the surgery was determined in the post-surgery period of 72 hours at 24-hour intervals. 

No statistical alteration was noted between the analgesics studied during the three days after surgery, taking into consideration the absence or presence of ostectomy as a modifier of the search. The pain-relieving effect of nimesulide was comparable to dipyrone, as shown below:

In patients with lower molar extractions, both nimesulide and dipyrone monohydrate have a comparable pain-relieving effect.