Headache, fatigue, olfactory and gustatory dysfunctioning, nausea, dizziness, and anorexia are the most prevalent neurological manifestations of SARS-CoV-2.

A study aimed to determine the link between COVID-19 infection and neurologic diseases by examining the most recent articles on neurologic manifestations and comorbidities in coronavirus patients and the neuroinvasion mechanisms of coronavirus.

Databases such as Embase, PubMed, Web of Science and Scopus were searched to find out all the relevant studies. Analysis of the extracted data was done. Application of the I2 index was done. For assessing the heterogeneity of studies, a fixed-effects or random-effects model was utilized for pooled evaluation. Using Egger and Beeg's tests, the publication bias was examined.

In this literature review and meta-analysis of observational studies, 57 studies (31 case reports and 26 observational) were incorporated (including 6,597 coronavirus-infected patients). The most prevalent general symptoms and neurological symptoms observed among COVID-19 patients is shown in Table 1:

Cerebrovascular disease (4.3%) was the most prevalent neurological comorbidity in SARS-CoV-2. 

The cerebrovascular diseases can either occur as a vital complication or act as a risk factor for poor prognosis in SARS-CoV-2 people. Meningitis, encephalitis, and Guillain-Barre syndrome have also been found to be significant complications of coronavirus disease.