Various tryptamine analog is reportedly effective in the treatment of acute cluster. However, the adverse effects such as bradycardia and heart failure is a matter of concern. In this study, Yasuo Ito et al reported the significant positive effect of Naratriptan as a preventive medicine for a cluster headache because of the longer the biological half-life in comparison to other triptans.

Naratriptan has been stated to decrease the incidence of cluster headache. The objective of this investigation was to define whether Naratriptan is efficient as a prophylactic medication for cluster headache in Japan. 

The analysis conducted with 43 participants who obtained Naratriptan in between April 2009 to April 2015 at three centers; Saitama Neuropsychiatric Institute, Saitama Medical University International Medical Center, and Department of Neurology, Saitama Medical University. Naratriptan was prescribed to be taken before went to bed. 

A total of 13 females and 30 males were present in the analysis. Out of 43 participants, only 21 received Naratriptan and other 22 received other preventive medications. In total 37 patients out of 43 able to obtain an improvement of cluster headache on Naratriptan.

Naratriptan has been recommended as preventive medicine for cluster headache due to its longer the biological half-life than the other Triptans. The internal application of Naratriptan two hours prior to the attacks seems to produce a good response within individuals with cluster headache.