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This study aimed to explore the efficacy and safety of dexmedetomidine in addition to local anesthesia for postsurgery pain management following lumbar surgery.
This systematic review and meta-analysis supported the use
of dexmedetomidine infiltration as a safe and effective adjunct therapy for pain
control following lumbar surgery.
This study aimed to
explore the efficacy and safety of dexmedetomidine in addition to local
anesthesia for postsurgery pain management following lumbar surgery.
The Web of Science,
PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, and
Chinese BioMedical database were explored with search terms- 'lumbar',
'dexmedetomidine', and 'infiltration'. A random-effect model was utilized to
execute the meta-analysis.
This review comprised of 6 randomized trials with 330
patients who had lumbar surgery. A significant reduction in postoperative
visual analogue scale (VAS) scores were observed with the use of
dexmedetomidine. The total supplemental analgesic usage was also decreased
along with extended median time to first rescue analgesia, and decreased nausea
or vomiting.
Wound infiltration with dexmedetomidine appears to be a safe
adjunct for postoperative pain relief following lumbar surgery. But, there is a
requisition for additional studies to assess the associated side effects, if
any.
Minerva Anestesiologica
Wound infiltration of dexmedetomidine as an adjunct to local anesthesia in postoperative analgesia for lumbar surgery: a systematic review and meta-analysis
Hui Dong et al.
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