For post-cesarean section pain management, tramadol exhibited better analgesic efficacy than lidocaine at 2 hours and up to 24 hours.

A was performed to evaluate placebo (saline), lidocaine, and tramadol intraoperative wound infiltration to alleviate post-cesarean section wound pain during initial 24 hours.

In this multi-center, double-blinded, parallel, prospective randomized controlled trial, 99 participants were randomly allocated into 3 groups. Each group contained 33 pregnant females undergoing surgery under general anesthesia. The wound of patients was subcutaneously infiltrated with saline in 3rd group, 2 mg/kg tramadol in 2nd group, and 20 mL of 2% lidocaine solution in 1st group during surgery.

Using Yes-No-Don't Know (YNDK) Scale, assessment of postsurgery pain at 2, 4, 6, 12, and 24 hours was the major endpoint ascertained. The requirement for additional postoperative analgesia was the secondary endpoint ascertained.

The wound infiltration with lidocaine or tramadol was found to be efficacious in pain relief. Both demonstrated superiority over placebo. Wound infiltration with tramadol illustrated superiority to lidocaine in pain mitigation at 2 hours and up to 24 hours.

In women undergoing cesarean under general anesthesia, wound infiltration with tramadol exhibited a more prolonged pain mitigation effect than lidocaine lasting up to 24 hours. In terms of pain reduction, both tramadol and lidocaine demonstrated superiority over placebo.