Dipyrone is an N-methyl-D-aspartate (NMDA) antagonist. It would be able to decrease the pain sensitization during surgery, as well as in the postoperative period through the blockade of central sensitization. But no study has been done on the preemptive analgesia of dipyrone in oral and maxillofacial surgeries. Therefore, the results of the current study demonstrated that dipyrone decreased the perception of transoperative and immediate postoperative pain.

Various controversial clinical outcomes were seen by studies on preemptive analgesia in maxillofacial surgery, primarily due to the lack of a methodological pattern, besides a considerable variety of studied drugs. This study evaluates the efficacy of preemptive dipyrone in reducing trans- and postoperative pain in the third molar surgical extraction.

A total of 25 patients were selected and divided into two groups, one study and another was control. The study group comprised 1g Dipyrone preemptively administrated for the extraction of two third molars on the same side and control group comprised 1g dipyrone in the postoperative period immediately. The variable involved in the analysis were pain perceived through the visual analogue scale (VAS) in transoperative and immediate postoperative periods and over 12-h investigation period, time to rescue analgesia, amount of anaesthetic, duration of surgery, and analgesic consumption.

The findings were submitted to Student’s, and statistical differences were found in immediate and transoperative postoperative periods; however the other studied variables did not show any statistical differences.

The preemptive intake of dipyrone reduced the perception of immediate and transoperative postoperative pain when compared to its use following surgery only.