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Improvement in efficacy of pancreatin in cystic fibrosis with Omeprazole

Cystic fibrosis Cystic fibrosis
Cystic fibrosis Cystic fibrosis

In a double-blind, crossover fashion, this study aimed to explore the effect of adding Omeprazole to treatment with pancreatin on fecal fat excretion in adults with cystic fibrosis.

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Key take away

In cystic fibrosis patients, adjunct treatment with Omeprazole decreases fecal fat excretion given that an elevated dose of pancreatin (pancrease) is supplied.

Background

In a double-blind, crossover fashion, this study aimed to explore the effect of adding Omeprazole to treatment with pancreatin on fecal fat excretion in adults with cystic fibrosis.

Method

The impact of using 20 mg once a day Omeprazole along with pancreatin, two or four capsules three times a day, on fecal fat excretion was examined in 9 participants while taking Pancrease, two capsules three times a day (22.3% mean fecal fat excretion; range, 12% to 44%).

Result

The amount of fecal fat excreted was not considerably decreased by either doubling the dose of pancrease (mean, 19.6% [range, 10% to 34%]) or by adding Omeprazole to the lower dose of pancrease (mean, 16.4% [range, 6% to 32%]). In comparison with the two dosages of pancrease alone, combining Omeprazole with pancrease's higher dosage (4 capsules 3 times per day) remarkably minimized fecal fat elimination (mean, 10.7%; range, 4% to 25%).

Conclusion

In patients having cystic fibrosis with severe steatorrhea caused by pancreatic insufficiency, Omeprazole added to high doses of pancreatin (pancrease) appears to decrease fecal fat excretion and improve pancreatin's effectiveness.

Source:

Annals of Internal Medicine

Article:

Omeprazole enhances the efficacy of pancreatin (pancrease) in cystic fibrosis

Authors:

H G Heijerman et al.

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