In individuals diagnosed with periodontitis, scaling and root planing can effectively lower levels of C-reactive protein.

The influence of non-surgical therapy on plasma levels of C-reactive protein (CRP) was examined in a single-arm prospective clinical study.

Using the Clinical Periodontal Sum Score (CPSS), 30 individuals with advanced periodontitis were enlisted. Serum samples were taken from all individuals at baseline and one month following scaling and root planing (post-SRP) using venous whole blood samples. A very sensitive immunoturbidimetric assay was used to estimate high-sensitivity CRP (hs-CRP). With the aid of Wilcoxon signed-rank test, the data was examined. To evaluate relationships between hs-CRP and CPSS at baseline and post-SRP, Spearman's rank correlation analysis was used.

The post-SRP CPSS values were substantially lower than the baseline levels (z = 4.783). The post-SRP hs-CRP levels were also remarkably lower than the baseline values (z = 4.782). Additionally, a favorable correlation was found between the baseline levels of CPSS values and hs-CRP (ρ = 0.5703) and post-SRP values of CPSS and hs-CRP (ρ = 0.7507).

The severity of periodontitis, as indicated by the CPSS score, was associated with a proportional rise in serum CRP levels. These levels can be reduced by non-surgical therapy.