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This retrospective Mendelian randomization analysis investigated the potential causal relationship between constipation and hypertension.
Individuals with hypertension may have a higher chance of experiencing constipation and vice versa; suggesting hypertension may increase the risk of constipation.
This retrospective Mendelian randomization analysis investigated the potential causal relationship between constipation and hypertension.
A two-sample two-way Mendelian randomization analysis was performed. Genetic markers associated with constipation were sourced from a genome-wide association study encompassing individuals of European descent, consisting of 15,902 cases and 395,721 controls.
Similarly, genetic associations related to hypertension were obtained from a GWAS dataset of European ancestry, comprising 54,358 cases and 408,652 controls.
The genetic predisposition to hypertension was considerably related to a raised risk of constipation (OR: 3.459, 95% CI: 1.820–6.573, P < .001). However, in an inverse Mendelian randomization analysis, the causal effect of constipation on hypertension was observed (OR: 0.999, 95% CI: 0.987–1.011, P = .834). These associations remained consistent in sensitivity analyses, without evidence of multiple effects.
This study indicates a causal connection between hypertension and constipation.
Medicine
Causal relationship between hypertension and risk of constipation: A 2-way 2-sample Mendelian randomization study
Rong Wang et al.
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