Pediatric Helicobacter pylori infection is one of the most commonly leads to peptic ulcer. As concluded from the outcomes of this double-blinded randomized controlled trial, the  use of sequential therapy for 2 weeks can be an effective first-line treatment for Helicobacter pylori eradication in pediatrics.

To examine sequential therapy used for 14 days and antibiotic resistance of H. Pylori eradication in children.

A total of 87 children (mean age 13.5 years; 55 males) with H. pylori infection were enrolled in this study. The patients who were either triple therapy for 7 days (25 patients, 28.7%) or 14 days (24 patients, 27.6%), or sequential therapy for 14 days (38 patients, 43.7%) were investigated.

The use of sequential therapy for 14 days was significantly better to 7-day triple therapy (97.4% vs. 80%), and was better than triple therapy for 14 days (83%). Resistant rate of clarithromycin was 22.2%, metronidazole was 16.7%, levofloxacin was 16.7%, and amoxicillin was 2.2% out of 54 patients with presented antibiotic resistance data. Clarithromycin resistance and eradication success were inversely related.

Sequential therapy for 14 days is superior to triple therapy, with a high eradication rate (>90%) in an area of high clarithromycin resistance in children with H.pylori infection.