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Efficacy of Upadacitinib in patients suffering from atopic dermatitis

Atopic Dermatitis Atopic Dermatitis
Atopic Dermatitis Atopic Dermatitis

This study examined the efficacy of sixteen weeks of Upadacitinib (a selective Janus kinase-1 inhibitor) for atopic dermatitis management in adults.

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Key take away

Upadacitinib is an efficacious treatment for individuals with moderate-to-severe atopic dermatitis, including those with prior poor response to Dupilumab and/or Baricitinib.

Background

This study examined the efficacy of sixteen weeks of Upadacitinib (a selective Janus kinase-1 inhibitor) for atopic dermatitis management in adults.

Method

In this multicentre prospective study, 47 patients from the Dutch BioDay registry managed with Upadacitinib were enrolled. Volunteers were evaluated at baseline, and following four, eight and sixteen weeks of treatment. Using clinician- and patient-reported outcome measurements, efficacy was investigated. With the aid of adverse events and laboratory assessments, safety was examined.

Result

The odds (95% confidence intervals) of attaining an Eczema Area and Severity Index (EASI) of <7 and Numerical Rating Scale (NRS) - pruritus score of ≤4 were found to be 73.0% (53.7-86.3) and 69.4% (48.7-84.4) respectively. In patients who did not respond well to Dupilumab and/or Baricitinib, as well as in patients who were unaware of these therapies or who had discontinued them due to side effects, Upadacitinib's effectiveness was comparable.

Notably, 14 patients (29.8%) stopped using Upadacitinib because it was not effective (8.5%), had negative side effects (14.9%), or both (6.4%). Herpes simplex (n = 6, 12.8%), Acneiform eruptions (n = 10, 21.3%), nausea (n=4, 8.5%), and airway infections (n = 4, 8.5%) were the most frequently reported side effects.

Conclusion

In atopic dermatitis-affected adults, including those with prior unsatisfactory response to Dupilumab and/or Baricitinib treatment, Upadacitinib is a promising therapeutic option.

Source:

Acta Dermato-Venereologica

Article:

Effectiveness of Upadacitinib in Patients with Atopic Dermatitis including those with Inadequate Response to Dupilumab and/or Baricitinib: Results from the BioDay Registry

Authors:

Boesjes CM et al.

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