The solutions used for submucosal injection  helps to isolate the lesion from the muscularis propria to permit overall resection of the gastric lesion. Both the Sodium hyaluronate and sodium carboxymethylcellulose injections used in this prospective randomized controlled trial had comparable outcomes for gastric endoscopic submucosal dissection.

To study the efficacy of sodium carboxymethylcellulose (SCMC) 1.0% compared to that of Sodium hyaluronate (SH) 0.4% in endoscopic submucosal dissection (ESD) of gastric neoplasms.

Overall 60 patients were divided into SH groups and SCMC groups with 30 patients in each group.  The duration of ESD was regarded as primary end point. En bloc and starting resection rates, hemostases, injectant quantity, ease of treatment (VAS, visual analog scale), number of adverse events, and percentage of ulcer healing after 8 weeks of the ESD procedure were considered as secondary endpoints.

The duration of ESD did not significantly vary between the two groups. No differences between the SH groups and SCMC groups concerning any secondary endpoints found. There were no serious adverse events.

Both the groups had comparable outcomes concerning duration, treatment, and ease and safety of gastric ESD treatment.