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This trial aimed to explore if a preoperative intravenous dose of dexamethasone minimizes pain, swelling, and analgesic use after periodontal flap surgery.
Preoperative
administration of dexamethasone alleviates swelling and pain within the first
postsurgery week after periodontal surgery.
This trial
aimed to explore if a preoperative intravenous dose of dexamethasone minimizes
pain, swelling, and analgesic use after periodontal flap surgery.
This randomized controlled, crossover trial incorporated 37 individuals planned for 2 identical periodontal surgeries under intravenous sedation. Participants were segregated to receive 2 mL (8mg) dexamethasone sodium phosphate or 2 mL of intravenous solution (placebo) before the 1st operation, and 2 mL of the other solution before the 2nd operation.
Using a standardized regimen of ibuprofen (600 mg) and acetaminophen
(325 mg), the management of postsurgery discomfort was done. A smartphone
application was utilized for recording self-evaluated pain and swelling scores
using 21-point numerical (NRS-21) and 4-point verbal (VRS-4) rating scales, and
also the number of analgesics at 12-, 24-, 48-, 72-, 168-, and 336-hours after
each operation.
The NRS-21 data indicated that
dexamethasone is linked with a considerable decline in swelling (at 12, 24, 48,
and 168 hours) and pain (at 12, 24, 48, and 72 hours) after surgery in
comparison with placebo.
After surgery, the VRS-4 data
illustrated a remarkable decrease in swelling (at 12, 24, and 168 hours) and
pain (at 12, 72, and 168 hours) with dexamethasone. There were no vital
differences in the no. of tablets of acetaminophen or ibuprofen between both
groups.
Intravenous
dexamethasone seems to be a valuable
adjunct for perioperative management of pain and swelling in patients undergoing
periodontal flap surgery.
Journal of periodontology
Effect of intravenous dexamethasone on post-operative pain and swelling following periodontal flap surgery: A randomized controlled trial of patient centered outcomes
Michael P Vieth et al.
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