In people with atopic dermatitis, antioxidants appear to be a safe and effective intervention, specifically when supplemented with topical vitamin B12 and oral vitamin D.

A systematic review and meta-analysis were conducted to investigate the safety and efficacy of antioxidants treatment in atopic dermatitis (AD) people.

Electronic databases such as Cochrane Library, Embase, and Medline were explored to find out relevant trials. Extraction of alteration from baseline in itch score and severity was done from individual studies and pooled utilizing random effects. Overall, 18 trials incorporating 763 subjects with AD were eligible.

Antioxidants were related to a substantial decrease in the severity of diseases, but not with the itch score. No major side effects were observed. Antioxidants were related to a remarkable lowering in the severity score irrespective of the severity of the disease at baseline and intervention duration, as revealed by the subgroup assessment.

Despite that, antioxidants had an add-on advantage only in offspring but not in adults. A significantly lower severity score was linked with topical vitamin B12, oral supplementation with vitamin D, combined vitamins A, D and E, and combined vitamins D and E. A profound heterogeneity was seen between the studies. Following the exclusion of the sources of study heterogeneity, the effect estimates did not significantly alter.

Antioxidants may be a safe and effective intervention for treating AD in pediatric patients too.