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The pain relieving efficacy and safety of VVZ-149 injections has been been explored for pain of moderate to severe intensity after gastrectomy.
VVZ-149 is an analgesic candidate
which acts as a glycine transporter type 2 (GlyT2)
blocker and the serotonin receptor 5 hydroxytryptamine 2 A (5-HT2A)
antagnonist. This study randomized,
parallel-group, double-blind study the use of
VVZ-149 injections to relieve pain and decrease opioid consumption in
patients undergoing laparoscopic and robot assisted laparoscopic gastrectomy.
The pain relieving efficacy and
safety of VVZ-149 injections has been been explored for pain of moderate to
severe intensity after gastrectomy.
A total of 60 patients undergoing
laparoscopic and robot assisted laparoscopic gastrectomy were included in this
randomized double-blind study. These patients were subjected to a 10 hour
intravenous infusion of VVZ-149 injections or placebo, started almost 1 hour
prior to the execution of surgical suturing.
Severity of pain and opioid usage
via patient-controlled analgesia and rescue analgesia provided "as
required" were regarded were regarded as the main outcome measures.
Efficacy of treatment was further determined in a subpopulation needing early
rescue medicine.
Along with lesser demands for
patient-controlled analgesia, a lower pain intensity was observed in the
VVZ-149 (30 patients) as compared to placebo (29 patients). The pain intensity
was statistically significant at 4 hours post-emergence (p < 0.05), with a
29.5% reduction in opioid usage for 24 hours. VVZ-149 also lead to 32.6% less
opioid usage for 24 hours and reduced pain intensity in the rescued subgroup.
VVZ-149 proved to effective in
decreasing postoperative pain and opioid needs. Patients with early rescue
requirement had greater advantage from VVZ-149, thereby confirming that VVZ-149
may help in providing pain relief and reduce excessive opioid consumption
postoperatively.
Pain Medicine
Role of VVZ-149, a Novel Analgesic Molecule, in the Affective Component of Pain: Results from an Exploratory Proof-of-Concept Study of Postoperative Pain following Laparoscopic and Robotic-Laparoscopic Gastrectomy
Inkyung Song et al.
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