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A trial was conducted to evaluate the effectiveness of H. pylori elimination treatment using a four-drug combination of Tinidazole, Tetracycline, Bismuth, and Rabeprazole in people with duodenal ulcers.
In patients with duodenal ulcers, a combination of Tinidazole, Tetracycline, Bismuth, and Rabeprazole is highly efficient in H. pylori elimination.
A trial was conducted to evaluate the effectiveness of H. pylori elimination treatment using a four-drug combination of Tinidazole, Tetracycline, Bismuth, and Rabeprazole in people with duodenal ulcers.
Subjects diagnosed with duodenal ulcers underwent gastrointestinal endoscopy, gastric mucosa biopsy for a rapid urease test, and histopathology to identify H. pylori bacteria both before and following therapy. A 14-day regimen of Tinidazole, Tetracycline, Bismuth, and Rabeprazole was given for eliminating H. pylori.
As per the intention to treat and per protocol analysis, the success rate for H. pylori elimination was 82.4% and 91.3%, respectively. Compared to females' success rate of 70.6%, males had an elimination rate of 96.0%.
Men had better H. pylori elimination outcomes than women when treated with a combination of Tinidazole, Tetracycline, Bismuth, and Rabeprazole.
Gastroenterology Insights
Efficacy of Helicobacter pylori Eradication Based on Rabeprazole–Bismuth–Tetracycline–Tinidazole Regimen in Vietnamese Patients with Duodenal Ulcers
Liem Thanh Nguyen et al.
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