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This study examined the influence of oral ibuprofen sustained release (SR) premedication on the effectiveness of buccal infiltration (BI) in managing pain during single-visit root canal treatment and after the procedure.
Premedicating with Ibuprofen SR premedication enhances buccal infiltration anaesthetic efficacy and relieves pain during and after root canal procedure in mandibular molars with apical pulpitis.
This study examined the influence of oral ibuprofen sustained release (SR) premedication on the effectiveness of buccal infiltration (BI) in managing pain during single-visit root canal treatment and after the procedure.
Overall, 60 patients with symptomatic pulpitis and apical periodontitis in mandibular molars were randomized to 2 groups. Group SR was given ibuprofen SR dosed as 800 mg while Group PL received a placebo capsule, both administered 1 hour before an Articaine BI 3.6 mL injection. Pain levels were measured using a modified visual analogue scale, with postoperative assessments conducted at 6 hours, 1 day and 2 days.
A significantly greater anaesthetic success rate (73.3%) in Group SR than in Group PL (46.7%) (p < 0.05). Additionally, Group PL experienced notably higher levels of pain during the root canal and afterwards compared to Group SR (p < 0.05).
The use of Ibuprofen SR before the root canal therapy enhanced the effectiveness of primary BI in mandibular molars with symptomatic irreversible pulpitis and provided pain relief at both 6 hours and after 2 days.
Australian Endodontic Journal
The effect of ibuprofen sustained release oral premedication on intraoperative and postoperative pain: A randomised clinical trial
Marian Ahmed Hossam et al.
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