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Osteoarthritis is a prevalent chronic disease and one of the most common causes of disability.
Collagen usage is ever increasing as it has
been proved to offer satisfactory results in the treatment of osteoarthritis
(OA). The results of the current meta-analysis state that oral administration
of collagen decreases the symptoms of OA, as both the total WOMAC index and VAS
score reduced significantly in this analysis.
Osteoarthritis is a prevalent chronic
disease and one of the most common causes of disability. Collagen provides
satisfactory results for OA, but, the possible beneficial effects of collagen
for OA treatment are presently controversial. The present meta-analysis aimed
to evaluate the impact of collagen-based supplements on the symptoms of OA.
PubMed-Medline, Scopus, and Google Scholar
databases were explored for randomized placebo-controlled trials examining the
effect of orally administered collagen on OA symptoms. Visual Analog Scale
(VAS) and/or Western Ontario and McMaster Universities Osteoarthritis Index
(WOMAC) were used to analyse the results. Meta-analysis was carried out using a
generic inverse variance method and random-effects model. The I2 statistic
index method was used to test the heterogeneity.
Collagen treatment significantly reduced
the score of the total WOMAC index i.e., WMD - 8.00 with 95% CI - 13.04,
- 2.95; p = 0.002. Following the subgroup analysis of the WOMAC subscores, the
collagen supplementation also significantly decreased the stiffness subscore i.e.,
WMD - 0.41 with 95% CI - 0.74, - 0.08; p = 0.01, on the other hand pain as, WMD
- 0.22 with 95% CI - 1.58, 1.13; p = 0.75 and the functional limitation as WMD
- 0.62 with 95% CI - 5.77, 4.52; p = 0.81, subscores did not possess
significant differences. Lastly, a significant reduction was observed in the
VAS score after administering collagen
i.e., WMD - 16.57; with 95% CI - 26.24, - 6.89; p < 0.001.
Oral Collagen found to effectively alleviate the OA symptoms
by the decreasing the total WOMAC index
and VAS score.
International Orthopaedics
Effect of collagen supplementation on osteoarthritis symptoms: a meta-analysis of randomized placebo-controlled trials
Juan Mario García-Coronado et al.
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