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A randomized, triple-blind, parallel, controlled, phase 3 trial was performed to explore the efficacy and the possible advantages of a combination of dexamethasone-bupivacaine with articaine-epinephrine as an anesthetic block following oral surgery.
In patients undergoing third molar
surgery, bupivacaine has superior efficacy in terms of alleviating post-surgery
pain as well as intake of analgesic drugs after surgery when compared to
articaine.
A randomized, triple-blind,
parallel, controlled, phase 3 trial was performed to explore the efficacy and
the possible advantages of a combination of dexamethasone-bupivacaine with
articaine-epinephrine as an anesthetic block following oral surgery.
Participants were segregated to (i) Experimental group (n=93) with a standard anaesthetic block: 40/0.005 mg/mL articaine-epinephrine and submucosal reinforcement with 0.8 mg dexamethasone-5% bupivacaine; and (ii) Control group (n=91) with standard block: 40/0.005 mg/mL articaine-epinephrine. For determining postsurgery pain, a visual analogue scale (VAS) was utilized.
The groups were homogeneous, without profound differences associated with epidemiological variables. The postsurgery pain among the 1st, 2nd and 7th postsurgery days was substantially reduced in the experimental group in comparison with the control group, as shown in Table 1:
Throughout the study period, drug
consumption was reduced in the experimental group.
For oral surgical procedures,
bupivacaine can be used as an alternative to articaine. Compared to articaine,
bupivacaine is more effective in decreasing patients' scores on the VAS and
minimizing the intake of analgesic drugs following third molar surgery.
Journal of Clinical Medicine
Comparative Study between the Combination of Dexamethasone and Bupivacaine for Third Molar Surgery Postoperative Pain: A Triple-Blind, Randomized Clinical Trial
Francisco Javier Quesada-Bravo et al.
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