Paracetamol, Mefenamic acid and Ibuprofen were found to have similar analgesic effectiveness, offering clinicians greater flexibility in pain management choices.

To evaluate and compare the analgesic efficacy of Paracetamol dosed at 600 mg, Ibuprofen dosed at 600 mg, and Mefenamic acid dosed at 500 mg.

This investigation employed a double-blind randomized controlled trial, involving a population of healthy subjects. The study sample comprised 30 subjects meeting specific inclusion criteria, which encompassed normal vital signs, while individuals with a history of allergy to non-steroidal anti-inflammatory drugs (NSAIDs) were excluded.

The participants were divided into three groups: Group 1 received Paracetamol (600 mg), Group 2 received Mefenamic acid (500 mg), and Group 3 received Ibuprofen (600 mg). Pain latency, defined as the onset of constant and intolerable pain, was assessed at 30-minute intervals.

Analysis via repeated measures ANOVA indicated a p-value of 0.1507, suggesting no statistically noteworthy difference in the analgesic efficacy among the groups.

The three analgesics under consideration exhibit comparable pain-relieving potency.