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This
study was performed to compare the efficacy of lansoprazole, (fast orally
disintegrating PPI), and dexlansoprazole (dual delayed-release PPI) in individuals
suffering from atypical GERD symptoms (hoarseness, globus, cough).
A greater response rate was found
for cough and globus symptoms in individuals having atypical gastroesophageal
reflux disease (GERD) following the eight-week proton pump inhibitor (PPI)
treatment with dexlansoprazole in comparison with lansoprazole.
This study was performed to compare the efficacy of lansoprazole, (fast orally disintegrating PPI), and dexlansoprazole (dual delayed-release PPI) in individuals suffering from atypical GERD symptoms (hoarseness, globus, cough).
The prospective, randomized, open-label trial
incorporated 232 subjects having atypical GERD symptoms with a total reflux
symptom index score > 10. Participants were randomly allocated to receive
oral administration of 30 mg lansoprazole, once daily prior to breakfast or
oral administration of 60 mg dexlansoprazole once daily prior to breakfast for
eight weeks. Comparing the symptoms response rate after an eight-week PPI treatment
between the two arms was the primary outcome parameter.
Following the eight-week PPI treatment, the dexlansoprazole-treated arm displayed a considerably greater response rate compared to the lansoprazole-treated arm in cough and globus, as shown in the table below:
As per the multivariate logistic
regression assessment, the usage of dexlansoprazole, dyslipidemia presence, and
typical GERD symptoms (heartburn and acid reflux) were found to significantly
predict the symptom response for cough. The usage of dexlansoprazole and
erosive esophagitis presence were found to predict the symptom response for
globus. In this study, no predictor for treatment response to hoarseness was
witnessed.
Compared
to lansoprazole once daily, administration of dexlansoprazole once daily for
eight weeks showed a substantially higher response rate in atypical GERD
individuals having globus and cough.
Journal of Gastroenterology and Hepatology
Comparison of the efficiency of two different proton pump inhibitor formula in treatment of patients with atypical gastroesophageal reflux disease: a prospective randomized study
Xi-Hsuan Lin et al.
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