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A study investigated skin healing properties of C. edulis aqueous leaf extract in the enzymatic assays and in the cell cultures.
The use of Carpobrotus edulis (C. edulis) is beneficial for
skin care and the management of skin problems.
A study investigated skin healing properties of C. edulis
aqueous leaf extract in the enzymatic assays and in the cell cultures.
With the
aid of light microscopy and scanning electron microscopy, the
micro-morphological assessment of leaves was performed. The phytochemical features
and antioxidant effect of C. edulis aqueous leaf extract were determined by
RP-LC-DAD-ESI-MS (reversed-phase liquid chromatography coupled with diode array
detection and electrospray ion trap mass spectrometry) and the in vitro
cell-free assays. With the aid of keratinocytes, fibroblasts, hyaluronidase,
elastase, and collagenase, an evaluation of biological activities was done.
C. edulis aqueous leaf extract illustrated flavonoids ([545.9 ± 26.0] g rutin equivalents/kg dry extract), high carbohydrates (28.59% ± 0.68%), and total phenols ([101.9 ± 6.0] g gallic acid equivalents/kg dry extract). As per RP-LC-DAD-ESI-MS, hydroxycinnamic acids (51.96%), followed by tannins (14.82%) and flavonols (11.32%) were predominantly present.
The extract was not cytotoxic. Moreover, it exhibited a
dose-dependent and strong antioxidant effect.
The extract was found to suppress hyaluronidase (100% at 1000 µg/mL) and
collagenase (> 90% at 500 µg/mL). In the cell culture experiments, C. edulis
aqueous leaf extract raised wound closure and production of collagen, which was
consistent with its elevated polyphenol content.
C. edulis has significant antioxidant properties that
make it suitable to be used in the preparation of topical formulations with antiaging
and cicatrizing properties. Its use for skincare purposes can be an eco-friendly
solution to minimize its invasiveness in the environment.
the Journal of Integrative Medicine
Carpobrotus edulis (L.) N.E.Br. extract as a skin preserving agent: From traditional medicine to scientific validation
Miriam Bazzicalupo et al.
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