Using a combination of beetroot, watermelon, and ginger juice could be a potentially effective approach to enhance clinical outcomes in assisted reproductive technology without causing any adverse effects.

A prospective randomized study was conducted to investigate whether supplementing with ginger, watermelon, and beetroot juice could enhance endometrial receptivity and clinical outcomes of intracytoplasmic sperm injection (ICSI) cycles.

In total, 436 female subjects undergoing ICSI cycles were recruited and randomly assigned in a 1:3 ratio to either the control group (n=109) or the supplementation group (n=327). All volunteers were provided nutritional guidance before starting the treatment. The volunteers in the supplementation group were instructed to daily consume a homemade juice comprising fresh beetroot, watermelon, and ginger, starting from the day the embryo was transferred until the pregnancy test. Conversely, volunteers in the control group did not adhere to the juice supplementation protocol.

Employment of generalized linear models adjusted for potential confounding factors such as the number of transferred embryos, endometrial thickness during embryo transfer, body mass index (BMI), and female age, was done. To assess the effect of supplementing juice on the clinical outcomes of ICSI, and to compare means between groups, a Bonferroni post hoc test was conducted.

Patient and cycle characteristics were evenly distributed between both groups. As depicted in Table 1, the supplementation group exhibited substantially greater implantation rates and clinical pregnancy rates when compared to the control group.

The findings suggested a potential positive impact of ginger, watermelon, and beetroot juice supplementation on reproductive health, making this approach a viable consideration in the pursuit of improved outcomes in assisted reproductive technology.